FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Su(var)205, Orc2
FlyBase ID
FBig0000104776
Interaction Network
Interactions Browser links
Su(var)205 network
Orc2 network
Reported Interactions
FBrf0099650-1a.AF.WB
Reference
Pak et al., 1997
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 4embryonic stage 3embryonic cycle 6embryonic cycle 5embryonic cycle 8embryonic cycle 7embryonic cycle 3embryonic cycle 4embryonic cycle 9embryonic stage 2
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Su(var)205 

HP1

bait
Orc2 

DmORC2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryo of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Pak et al., 1997)
FBrf0099650-4.coIP.WB
Reference
Pak et al., 1997
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 4embryonic stage 3embryonic cycle 6embryonic cycle 5embryonic cycle 8embryonic cycle 7embryonic cycle 3embryonic cycle 4embryonic cycle 9embryonic stage 2
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Orc2 

DmORC2

bait
Su(var)205 

HP1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryo of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Pak et al., 1997)
FBrf0099650-7.PD.WB
Reference
Pak et al., 1997
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Su(var)205 

HP1

bait

FLAG tag

Su(var)205 
Su(var)205 
Orc2 

DmORC2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Su(var)205 
shadow domain
necessary binding region
aa 170-206

coordinates relative to Su(var)205-PA

Su(var)205 
chromodomain
necessary binding region
aa 1-31

coordinates relative to Su(var)205-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from wild-type embryonic extract.

(Pak et al., 1997)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)