FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
Ubr3, cos
FlyBase ID
FBig0000105055
Interaction Network
Interactions Browser links
Ubr3 network
cos network
Reported Interactions
FBrf0232422-3.coIP.WB
Reference
Li et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Ubr3 

UBR

bait

GFP tag

Ubr3 
cos 

Cos2

prey

HA tag

cos 
cos 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Ubr3 
UBR domain
sufficient binding region
aa 222-292
cos 
N-terminal motor domain
sufficient binding region
aa 1-389

"ΔC3" construct

cos 
N-terminal motor domain
necessary binding region
aa 1-389

"ΔN1" construct

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Li et al., 2016)

The Ubr3-cos interaction is enhanced upon co-transfection of cells with hh, with a concomitant increase in cos ubiquitination.

(Li et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)