FB2026_03 , released September 17, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
Top2, scf
FlyBase ID
FBig0000105136
Interaction Network
Interactions Browser links
Top2 network
scf network
Reported Interactions
FBrf0105261-1.coIP.WB
Reference
Kobayashi et al., 1998
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 16blastoderm stagegastrula stageembryonic stage 8dorsal closure stageembryonic stage 9embryonic stage 6early extended germ band stageembryonic cycle 3extended germ band stageembryonic stage 4embryonic cycle 9embryonic stage 2late extended germ band stageembryonic stage 5embryonic stage 11embryonic stage 3embryonic stage 12embryonic stage 15embryonic cycle 6embryonic cycle 5embryonic cycle 8embryonic cycle 7embryonic stage 13embryonic cycle 4embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
scf 

SCF

bait
Top2 

topoII

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Bait endogenous to embryonic nuclear extract.

(Kobayashi et al., 1998)

Prey endogenous to embryonic nuclear extract.

(Kobayashi et al., 1998)

The Top2 interaction was only tested for the nuclear scf-PB isoform, not the endoplasmic reticulum targeted scf-PA isoform.

(Kobayashi et al., 1998)
FBrf0105261-2.coIP.WB
Reference
Kobayashi et al., 1998
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 1embryonic stage 16blastoderm stagegastrula stageembryonic stage 8dorsal closure stageembryonic stage 9embryonic stage 6early extended germ band stageembryonic cycle 3extended germ band stageembryonic stage 4embryonic cycle 9embryonic stage 2late extended germ band stageembryonic stage 5embryonic stage 11embryonic stage 3embryonic stage 12embryonic stage 15embryonic cycle 6embryonic cycle 5embryonic cycle 8embryonic cycle 7embryonic stage 13embryonic cycle 4embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Top2 

topoII

bait
scf 

SCF

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Bait endogenous to embryonic nuclear extract.

(Kobayashi et al., 1998)

Prey endogenous to embryonic nuclear extract.

(Kobayashi et al., 1998)

The Top2 interaction was only tested for the nuclear scf-PB isoform, not the endoplasmic reticulum targeted scf-PA isoform.

(Kobayashi et al., 1998)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)