FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Diap2, Drice
FlyBase ID
FBig0000107691
Interaction Network
Interactions Browser links
Diap2 network
Drice network
Reported Interactions
FBrf0192581-2.coIP.WB
Reference
Leulier et al., 2006
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Diap2 

DIAP2

bait

TAP tag

Drice 

drICE

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of 293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Leulier et al., 2006)

Diap2 interacts with Drice but not with Dcp-1.

(Leulier et al., 2006)
FBrf0201142-1.coIP.WB
Reference
Ribeiro et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Diap2 

DIAP2

bait

TAP tag

Diap2 
Diap2 
Diap2 
Diap2 
Drice 

drICE

prey

V5 tag

Drice 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Drice 
IAP Binding Motif
mutation disrupting interaction
aa 29

A29V

Diap2 
BIR2 and BIR3 domains
sufficient binding region
aa 78-338
Diap2 
BIR3 domain residue 249
mutation disrupting interaction
aa 249

C249G

Diap2 
BIR3 domain residue 263
mutation disrupting interaction
aa 263

D263A

Diap2 
noncleavable DIAP2 D100E mutant
mutation decreasing interaction
aa 100

D100E

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Ribeiro et al., 2007)

The Drice-Diap2 interaction is disrupted by treatment with NH2OH.

(Ribeiro et al., 2007)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)