FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Mitofilin, Pink1
FlyBase ID
FBig0000116688
Interaction Network
Interactions Browser links
Mitofilin network
Pink1 network
Reported Interactions
FBrf0238266-1.coIP.WB
Reference
Tsai et al., 2018
Description
physical association
Assay
Collection
Source/Stage
organism / pupal stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mitofilin 

dMIC60

bait
Pink1 

dPINK1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was mitochondrial fractions of wild-type or mutant pupae; bait produced from endogenous gene; prey produced from endogenous gene.

(Tsai et al., 2018)
FBrf0238266-2.PD.WB
Reference
Tsai et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Mitofilin 

dMIC60

bait

GST tag

Mitofilin 
Mitofilin 
Pink1 

dPINK1

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Mitofilin 
interaction domain
sufficient binding region
aa 92-223,547-739

coordinates relative to Mitofilin-PC

Mitofilin 
C-terminal domain
necessary binding region
aa 547-739

coordinates relative to Mitofilin-PC

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced as a recombinant fusion protein in bacterial system.

(Tsai et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)