FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Sema2a
FlyBase ID
FBig0000119907
Interaction Network
Interactions Browser links
Sema2a network
Reported Interactions
FBrf0243223-10.CH.MW
Reference
Rozbesky et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Sema2a 

Sema2a

neutral component

His tag

Sema2a 
Sema2a 

Sema2a

neutral component

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Sema2a 
interaction domain residue 279
mutation disrupting interaction
aa 279

C279S

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Sema2a exists as a dimer in solution.

(Rozbesky et al., 2019)

Interaction in vitro; protein produced as a recombinant fusion protein in HEK293 cells.

(Rozbesky et al., 2019)
FBrf0243223-11.CM.WB
Reference
Rozbesky et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Sema2a 

Sema2a

neutral component

His tag

Sema2a 
Sema2a 

Sema2a

neutral component

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Sema2a 
interaction domain residue 279
mutation disrupting interaction
aa 279

C279S

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Sema2a exists as a dimer in solution.

(Rozbesky et al., 2019)

Interaction in vitro; protein produced as a recombinant fusion protein in HEK293 cells.

(Rozbesky et al., 2019)
FBrf0243223-2.XC
Reference
Rozbesky et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Sema2a 

Sema2a

neutral component

His tag

Sema2a 
Sema2a 

Sema2a

neutral component

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Sema2a 
interaction domain
sufficient binding region
aa 27-671

27Y-671K

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Sema2a forms a dimer in crystallo.

(Rozbesky et al., 2019)

Interaction in vitro; protein produced as a recombinant fusion protein in HEK293 cells.

(Rozbesky et al., 2019)
External Crossreferences and Linkouts ( 0 )
References (1)