FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Ank2, pk
FlyBase ID
FBig0000121962
Interaction Network
Interactions Browser links
Ank2 network
pk network
Reported Interactions
FBrf0255277-1.coIP.WB
Reference
Chen et al., 2023
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
pk 

Pk

bait

HA tag

pk 
Ank2 

Ank2

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
pk 
Lim domain
necessary binding region
unspecified

Deleted from the common exon fragment aa 14-963.

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Chen et al., 2023)

The PK and Sple isoforms of pk both interact with Ank2.

(Chen et al., 2023)
FBrf0255277-2.coIP.WB
Reference
Chen et al., 2023
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Ank2 

Ank2

bait

V5 tag

Ank2 
pk 

Pk

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Ank2 
ankyrin repeat region
mutation disrupting interaction
unspecified

Deleted from the common exon fragment aa 1 -1126.

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Chen et al., 2023)
External Crossreferences and Linkouts ( 0 )
References (1)