FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Tbp, Antp
FlyBase ID
FBig0000123313
Interaction Network
Interactions Browser links
Tbp network
Antp network
Reported Interactions
FBrf0260147-4.FRET.FM
Reference
Villarreal-Puente et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Tbp 

Tbp

fluorescence donor

CFP tag

Tbp 

Tbp

fluorescence donor

CFP tag

Tbp 

Tbp

fluorescence donor

CFP tag

Antp 

Antp

fluorescence acceptor

Venus tag

Antp 
Antp 
Antp 

Antp

fluorescence acceptor

Venus tag

Antp 

Antp

fluorescence acceptor

Venus tag

Antp 
Antp 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Antp 
Homeodomain
mutation decreasing interaction
aa 245-363
Antp 
Poly Q domain
mutation decreasing interaction
aa 1-244
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was live HEK293 cells; fluorescence donor produced from tagged transgenic construct; fluorescence acceptor produced from tagged transgenic construct.

(Villarreal-Puente et al., 2024)

Tbp forms a trimer with Antp-Ubx that experesses the Venus tag via bimolecular fluorescence complementation. Deletion of Antp\'s homeodomain disrupts its dimerization with Ubx and results in a decreased interaction with Tbp.

(Villarreal-Puente et al., 2024)
External Crossreferences and Linkouts ( 0 )
References (1)