FB2026_02 , released June 18, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
sev
FlyBase ID
FBig0000123413
Interaction Network
Interactions Browser links
sev network
Reported Interactions
FBrf0261119-2.EM
Reference
Cerutti et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
sev 

sev

self
sev 
sev 

sev

self
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sev 
ECD domain
sufficient binding region
aa 123-2119

furin cleavage site aa 2038-2046 removed; coordinates relative to sev-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

sev monomer and dimer interacts with boss monomer and dimer.

(Cerutti et al., 2024)

Interaction in vitro; protein produced as a recombinant fusion protein in baculovirus and insect cell system.

(Cerutti et al., 2024)
FBrf0261119-6.LS
Reference
Cerutti et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
sev 

sev

self
sev 

sev

self
sev 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sev 
ECD domain
sufficient binding region
aa 123-2119

furin cleavage site aa 2038-2046 removed; coordinates relative to sev-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; protein produced as a recombinant fusion protein in baculovirus and insect cell system.

(Cerutti et al., 2024)

Decreasing pH increases sev homodimerization.

(Cerutti et al., 2024)
External Crossreferences and Linkouts ( 0 )
References (1)