FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hsc70-3, WRNexo
FlyBase ID
FBig0000123625
Interaction Network
Interactions Browser links
Hsc70-3 network
WRNexo network
Reported Interactions
FBrf0262127-1.coIP.MS
Reference
Wu et al., 2025
Description
physical association
Assay
Collection
Source/Stage
organism / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
WRNexo 

WRNexo

bait

HA tag

Hsc70-3 

Hsc70-3

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult flies of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Wu et al., 2025)
FBrf0262127-2.coIP.WB
Reference
Wu et al., 2025
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
WRNexo 

WRNexo

bait

HA tag

Hsc70-3 

Hsc70-3

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of HEK293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Wu et al., 2025)
FBrf0262127-3.PD.WB
Reference
Wu et al., 2025
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsc70-3 

Hsc70-3

bait

GST tag

WRNexo 

WRNexo

prey

His tag

WRNexo 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
WRNexo 
interaction domain
sufficient binding region
aa 127-327
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait and prey produced as recombinant fusion proteins in bacterial system.

(Wu et al., 2025)
External Crossreferences and Linkouts ( 0 )
References (1)