Shepherd, J.C., Walldorf, U., Hug, P., Gehring, W.J. (1989). Fruit flies with additional expression of the elongation factor EF-1 live longer.  Proc. Natl. Acad. Sci. U.S.A. 86(19): 7520--7521.

FBrf0050863

Research paper

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

PMC298096 (PMC) (EuropePMC)