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Citation
Tamkun, J.W., Kahn, R.A., Kissinger, M., Brizuela, B.J., Rulka, C., Scott, M.P., Kennison, J.A. (1991). The arflike gene encodes an essential GTP-binding protein in Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 88(): 3120--3124.
FlyBase ID
FBrf0054967
Publication Type
Research paper
Abstract

We have identified a Drosophila gene (arflike, arl) encoding a protein that is structurally related (approximately 55% identity) to the ADP-ribosylation factors (ARFs) of yeast and mammals. Biochemical analyses of purified recombinant arl-encoded protein revealed properties similar to the ARF proteins, including the ability to bind and hydrolyze GTP. Clear functional differences between arl and ARF proteins, including a complete lack of ARF activity, suggest that arl is not a functional homolog of ARF. A recessive lethal arl mutation was recovered, demonstrating that the arl locus is an essential gene. We conclude that the arl locus encodes an essential member of the ARF subfamily of small GTP-binding proteins in Drosophila.

PubMed ID
PubMed Central ID
PMC51397 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (2)
    Alleles (3)
    Genes (2)
    Transgenic Constructs (1)