Subject: M(2)LS1/M(2)23AB/dppHin
Michael, Aubrey,
I'm not quite sure how to handle the case described in my
email to Detlef Wolf (below).
M(2)LS1 (= M(2)23AB in the Grey Book) was mapped to 22D-23B
by Lindsley, Sandler et al. (1972).
We drew the conclusion that what we originally called the 'Hin-d'
locus (haplo-insufficiency near dpp) must be the entity that equates
with M(2)LS1 (Spencer et al., 1982).  In this paper, we also noted
that Hin-d did NOT have a Minute phenotype.  Further, in Irish and
Gelbart (1987), we concluded that Hin-d was not an independent locus but
rather was due to loss of one copy of the dpp gene, or more precisely
due to complete knockout of one copy of its embryonic D/V patterning
function defined by the so-called dppHin region.
Neither Dan nor Larry had any notes that provided any information other
than what was in the 1972 segmental aneuploidy paper.
I have no idea why Michael renamed M(2)LS1 to M(2)23AB, since 23AB
is a different cytological position from L&S`s 22D-23B.  Michael, can
you help?
It seems like the current M(2)LS1 entry needs to be revised.  Here are
two options.
(1) {My preferred option, but I leave it to the keepers of the
genes Holy Grail.}
Make both M(2)LS1 and M(2)23AB synonyms for dpp, and add a text comment
somewhere in the genes record to the effect: 'The haplo-insufficient Minute
locus proposed to map near dpp (previously called M(2)LS1 or M(2)23AB,
Lindsley et al., 1972) is now thought to be the haplo-lethal but not
phenotypically Minute loss of dppHin function (Spencer et al., 1982;
Irish and Gelbart, 1987; Gelbart, pers. comm.).'
(2) Keep the M(2)LS1 gene listing in place, add the synonym M(2)23AB,
add the reference Lindsley et al. (1972) and add the same text statement:
'The haplo-insufficient Minute locus proposed to map near dpp (previously
called M(2)LS1 or M(2)23AB, Lindsley et al., 1972) is now thought to be
the haplo-lethal but not phenotypically Minute loss of dppHin function
(Spencer et al., 1982; Irish and Gelbart, 1987; Gelbart, pers. comm.).'
In reality, I think either option will clarify the situation.
Bill