Subject: serotonin receptor To Rachel Drysdale FLyBase Concerning the Atlanta 's poster about a new 5-HT2 Drosophila receptor, the 5-HT2Dro cDNA and genomic sequences have been deposited at the EMBL/Gene Bank under the accession numbers X81835 and X85407 respectively. This 5-HT2Dro is a newly (the fourth) cloned Drosophila serotonin receptor gene located in the third chromosome at 82C-82D. In contrast with the 3 previously published Drosophila 5-HT receptors which are of the 5-HT1 subtype, acting on the adenylyl cyclase, this 5-HT2Dro receptor displays a sequence, a gene organisation and a pharmacology typical of the mammalian serotonin 5-HT2 receptor type (5-HT2B subtype) acting on the PLC. So, in order to avoid confusion and in accordance with the new mammalian nomenclature, we propose (in a paper to be published in PNAS in June : Colas & al / Drosophila serotonin 5-HT2 receptor : co-expression with fushi-tarazu during segmentation, that I will send you by mail) that the 5-HTDro2A, 5-HTDro2B and 5-HT1Dro be renamed 5-HT1ADro, 5-HT1BDro and 5-HT7Dro respectively. Thanks from Luc Maroteaux IGBMC-CNRS-INSERM Strasbourg University BP 163 67404 ILLKIRCH Cedex FRANCE
