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Citation
Feger, G., Vassin, H., Su, T.T., Wolff, E., Jan, L.Y., Jan, Y.N. (1995). dpa, A member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.  EMBO J. 14(21): 5387--5398.
FlyBase ID
FBrf0085022
Publication Type
Research paper
Abstract

We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA replication defects in mitotically proliferating cells. In contrast, dpa is dispensable for endoreplication, a specialized cell cycle consisting of consecutive rounds of S phases without intervening mitosis. Our studies suggest an essential role for dpa in mitotic DNA replication but not in endoreplication. Thus, dpa is not a general replication factor but may play a specialized regulatory role in DNA replication.

PubMed ID
PubMed Central ID
PMC394648 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (3)
    Alleles (8)
    Genes (8)
    Insertions (1)
    Transgenic Constructs (1)