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General Information
Symbol
Dmel\dpa1
Species
D. melanogaster
Name
FlyBase ID
FBal0035049
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

BrdU incorporation in third larval instar brains is reduced in homozygotes compared to heterozygotes. There is a 5.0 fold increase in the percentage of mitotic cells in the mutant larval brain compared to wild type. Anaphase, telophase and prophase figures are not seen, instead 100% of figures appear arrested in a metaphase-like state. A large number of metaphase-like figures are seen in which a highly condensed chromosome mass is present. Abnormal mitotic spindles are seen that are either anastral or have poorly focused poles. 49% of figures (Class I) have chromosomes aggregated at the metaphase plate, while 51% (Class II) have chromosomes scattered along the metaphase-like spindle. The spindle is diffuse but more focused than in Class I. The mitotic chromosomes are abnormally condensed, with three classes of defects based on severity, in third instar larvae; 5% (Class I) have mild defects such as undercondensed chromosome arms. In 85% (Class II), mutant centromeres cannot be distinguished and chromosome arms are decondensed. In addition, sister chromatid cohesion is often lost. 10% (Class III) have underwound centromeres and chromosome arms are more decondensed than in Class II, having a "dumb-bell" morphology.

Pupal tissues disintegrate, leaving empty pupal cases. Dissected third instar larvae have no imaginal discs and the CNS is reduced in size. esg and sna staining reveals absence of the imaginal discs is due to failure of proliferation. In larvae BrdU incorporation indicates the cell cycle is either prolonged or blocked after the first division(s).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)