Open Close
Reference
Citation
Gossen, M., Pak, D.T.S., Hansen, S.K., Acharya, J.K., Botchan, M.R. (1995). A Drosophila homolog of the yeast origin recognition complex.  Science 270(5242): 1674--1677.
FlyBase ID
FBrf0085120
Publication Type
Research paper
Abstract

Genes from Drosophila melanogaster have been identified that encode proteins homologous to Orc2p and Orc5p of the Saccharomyces cerevisiae origin recognition complex (ORC). The abundance of the Drosophila Orc2p homolog DmORC2 is developmentally regulated and is greatest during the earliest stages of embryogenesis, concomitant with the highest rate of DNA replication. Fractionation of embryo nuclear extracts revealed that DmORC2 is found in a tightly associated complex with five additional polypeptides, much like the yeast ORC. These studies will enable direct testing of the initiator-based model of replication in a metazoan.

PubMed ID
PubMed Central ID
Related Publication(s)
Erratum

Drosophila homolog of yeast ORC: correction.
Gossen et al., 1996, Science 271(5254): 1349 [FBrf0087233]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Genes (3)