Subject: Re: DAPA/P110
Dear Aubrey,
The gene that we have called DAPA 10 years ago (!) does
not encode a protein mediating adhesion as we had thought initially.
We have never published anything on it and have dropped the project
long ago. Its transcript is located between 0 and - 10 kb on our
published map (Justice et al., Genes & Dev. 9, 534-546, 1995).
Homozygous deficiencies of the gene are fertile and viable and show
no obvious phenotype. Therefore, I would suggest that the tentative
name DAPA for this gene be eliminated. The product of the gene
is a 110 kDa protein, which is homologous to prosaposin from vertebrates
(rat, mouse, man). Therefore, a better name for the gene would be
'sap-r' for 'saposin-related', as we have called it later when the
first vertebrate homologues were found.
I hope this answers your questions. I am also sending this
message to Peter Bryant to make sure that he will also refer to it
in the future as sap-r.
With best regards,
Markus