Dear Rachel, Just to update you on the Drosophila PI3K originally called PI3K-92D. We now have a paper in press in EMBO Journal describing this Drosophila PI3K which we have renamed Dp110 (to be consistent with the nomenclature for these enzymes in other organisms) and the phenotypes generated by over-expression of activated and dominant negative forms of the protein. Also, we have remapped the gene to 92E12-13 (making the original name even less appropriate!). The sequence should be released into EMBL shortly, under accession number Y09070. Please let me know if there is any other information that might be of use to you. with best wishes, Sally Sally J. Leevers Ludwig Institute for Cancer Research University College London Branch