Subject: Help FlyBase - hhMir
Hi Ian and Artyom,
FlyBase minimally curates from the abstracts presented at the Annual
Drosophila Research Conference. In April, at the Chichago meeting, you
presented a slide (21B) in which you discuss a new hh allele - Mir.
Does this allele have any relationship to the gene Mir, Mirabile that is
described in FlyBase and in the Red Book?
I ask as the Red book states that Mir is not allelic to hh (other
information section), but then you have an allele Mir of hh. If this is
purely by chance then no problems, but if you are suggesting allelism between
hh and Mir then could you please provide your evidence for this.
Many thanks,
Eleanor Whitfield
FlyBase
>
Subject: RE: Help FlyBase - hhMir
Dear Eleanor:
hh-Mir is the same as Mir described in the Red Book, and it is indeed a gain-of-
function allele of hh. It causes ectopic hh expression in the anterior
compartment. Three reversions of hh-Mir have breaks at the hh locus and behave
as hh nulls or hypomorphs. hh-Mir itself complements hh nulls, which probably
led to the report that they are not allelic. Sorry we caused you this headache.
Best wishes,
Artyom