Subject: ADRC: 372A
Dear David,
I am writing in connection with your abstract for the upcoming Washington
DC ADRC:
'Serine protease/serpin balance regulates expression of the antifungal
peptide gene drosomycin in Drosophila.'
You describe three genes 'Ser1', 'Ser2' and 'Ser3', all new to FlyBase.
Do you have a cytological location for these that has been determined
independently of nec (such as by chromosome in situ hybridisation)?
Is there a one to one correspondence between any one of the Ser genes and
nec?
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: ADRC: 372A
The ser cluster maps at 43A1.2 by in situ hybridisation. There is some
evidence for Genetic complexity (Heitler et al 1993) but P element rescue
indicates that Ser3 is necrotic. Deletion of Ser2 alone gives no detectable
phenotype, while overlapping deletions of all 3 Serpins survives as an
adult for a short while before dying with an extreme necrotic phenotype.
David Gubb