Subject: Re: fs(2)TW1.1
Dear Rachel,
thank you for your mail. The information regarding γTub37C1 is the
following:
we identified a base pair substitution (G to A) in position 1027 of the
CDS, from the ATG. This produces an amino acid substitution from W to STOP
in position 352. The truncated protein lacks the last 105 C-terminal
amino acids, and we think it is very likely to be rapidly degraded.
Thank you in advance,
regards,
Gaia Tavosanis
> Dear Gaia,
>
> Thank you for your mail about γTub37C1 (γTub37CDTW1.1). We
> have the accession number AF081253 recorded for that allele but from
> simply viewing the Genbank record it is not clear what the mutant
> lesion is, with respect to the wild type sequence. For example is there
> a base pair substitution leading to an amino acid substitution? If you
> can summarise this for me in a few words I can incorporate this into
> the allele record, citing your mail as a personal communication
> including the data.
>
> Apologies for the delay in our reply to you - FlyBase have been at a
> meeting this week. Normal service has now been resumed.
>
> Regards,
>
> Rachel.
Gaia Tavosanis
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