Subject: ADRC-119 and 14W
Dear Eric,
We are currently curating the abstracts for the upcoming Bellevue
(Seattle) Annual Drosophila Research Conference, for FlyBase. I am
writing in connection with your abstracts:
'Characterization of protein complexes involved in bcd mRNA localization.'
You mention a gene that is new to FlyBase, DEK, and say it is 'the
Drosophila homolog of the DEK oncogene protein'.
FlyBase already has a gene which is a homolog of human DEK, namely:
\*a E(var)53E
\*z FBgn0015217
\*b 2-
\*c 53E
\*j species == Homo sapiens; gene == DEK;  OMIM:125264 
\*x FBrf0083118 == Dorn et al., 1995, Europ. Dros. Res. Conf. 14: 326
\*e Enhancer of variegation 53E
\*i E(var)2-53E
\*p The E(var)53E protein is related to the human DEK protein implicated
\*p in acute myeloid leukemia.
\*A E(var)53E1
\*z FBal0042525
\*x FBrf0083118 == Dorn et al., 1995, Europ. Dros. Res. Conf. 14: 326
\*i unnamed
\*o P-element activity
\*G FBti0012253 == P{hsneo.ry+}E(var)53E1
\*k Phenotypic class: enhancer | dominant { In(1)wm4h }
\*k Phenotypic class: female sterile | recessive
\*k Enhancer of PEV. Homozygotes are only semi-viable. Surviving females
\*k are sterile.
\*u Remobilisation of the P element reverts mutant phenotype.
Is this the same gene as your 'dDEK'.
If not, do you have a map location for DEK? It is nice if we can
keep as many gene records as possible anchored to the map.
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: ADRC-119 and 14W
Hi Rachel,
	I'm sorry that I haven't gotten back to you yet, but the reason
is that I have not yet been able to determine whether our DEK is the
same as E(var)53E. The map position of our genomic sequence places it
near the position reported by Dorn et al, but as we do not have
their sequence we cannot be sure it is the same gene. I have emailed
Dr. Reuter to request the sequence, but have yet to hear back. Do you
have access to the abstract reporting E(var)53E?
(FBrf0083118 == Dorn et al., 1995, Europ. Dros. Res.
	Conf. 14: 326)
	If you could forward the text of this abstract, it may contain
information which would allow us to determine whether we are dealing
with the same gene. I will be certain to let you know as soon as we
have good evidence either way.
			best,
				Eric Arn
Subject: Re: ADRC-119 and 14W
Dear Eric,
I am faxing you a copy of FBrf0083118. It may be as well to keep the
two records (E(var)53E and DEK) separate for now, but if you could give
me the map position of your genomic sequence (which you indicated that
you know) then that would be helpful. If you don't want to then that's
fine too - just let me know, and we will be patient. We can always
merge the E(var)53E and DEK records later, when things become clearer.
Thanks for getting back to me,
Rachel.
Subject: Re: ADRC-119 and 14W
Rachel,
	Our gene is placed in the Genome Project sequence at 53D. So,
as before, I think it is likely to be the same as E(var)53E but I am
awaiting a reply from Dr. Reuter to confirm this. Thanks for sending
the fax - the abstract is interesting but unfortunately does not answer
the identity question for us. Here's hoping you have a pleasant trip to
the states.
				Best,
					Eric