Subject: ADRC-062
Dear Tim,
We are currently curating the abstracts for the upcoming Bellevue
(Seattle) Annual Drosophila Research Conference, for FlyBase. I am
writing in connection with your abstract:
'The centrosomin locus encodes four isoforms, one of which is testis
specific and arrests cell division in mitosis when expressed
ectopically.'
You mention a gene that is new to FlyBase, dem.
You say that dem is very tightly linked to cnn. I imagine that this
map statement is based on molecular mapping, for example because the
dem transcription unit maps next to the cnn transcription unit. Would
you be able to confirm this for me, or otherwise give me a basis for
the map statement? It is nice if we can keep as many gene records as
possible anchored to the map, and I need to be able to formalise the
map statement if we are to be able to usefully record the location of
dem with respect to cnn.
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: ADRC-062
Dear Rachel,
Thanks for contacting me regarding 'dem', which I mentioned in my abstract.
We (Thom and I) are still undecided on what to name this gene and dem
(short for dementin) may be inappropriate considering what we now know
about the gene's function. Thom will call you tomorrow (Thurs) to discuss.
This gene maps VERY close to cnn physically. The two genes are divergently
transcribed and the transcription start sites are separated by a mere 134
bp.
Sincerely,
Tim
Subject: Re: ADRC-062
Hi Tim,
I gather after my phone conversation with Thom that this is what is to
be 'centrosomin's beautiful sister'. Could you confirm this for me
(sorry to be a nuisance - we have to have everything in writing
otherwise chaos ensues....)(even more than otherwise ......)
Rachel.
Subject: Re: ADRC-062
Hi Rachel,
Sorry I forgot to get back to you til now. I am very much in favor of
calling this new gene 'centrosomin's beautiful sister' (cbs), as
opposed to the name 'dementin' which was mentioned in the abstract I
submitted to the Drosophila Research Conference. I thank you much for
you help in settling this issue for us. The new name is very
appropriate.
Tim