Leblanc, P., Dastugue, B., Vaury, C. (1999). The integration machinery of ZAM, a retroelement from Drosophila melanogaster, acts as a sequence-specific endonuclease. J. Virol. 73(8): 7061--7064.
FlyBase ID
FBrf0110158
Publication Type
Research paper
Abstract
Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome of Drosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes and leads to ZAM insertion into the sequence 5'-GCGCGCg-3'. This unique property of ZAM will facilitate the development of new tools to study the integration process of retroelements.
