Gene or accession: CG8810, Dspt4
Gene annotation error
Gene Dspt4 has a mistake in the supporting evidence or functional assignment.
Comments: CG8810 is annotated correctly as a gene on the (-) strand having
homology to BolA protein, and is a predicted mevalonate kinase. Dspt4 is on
the (+) strand annotated as the Drosophila homolog of yeast Spt4 (correct) but
it is also annotated as a mevalonate kinase. The problem seems to lie in the
overlapping transcription units of these genes. BDGP cDNA LD44495 (5'
sequence) encodes the entire Dspt4 ORF but overlaps with 3' CK02143 and 3'
GH04687. LD16567, which encodes part of CG8810, is downstream from Dspt4 on
the opposite strand. Sequence data from our lab indicates that the LD44495 3'
end ((+) strand) is downstream from the 5' end of LD16567 ((-) strand).
Therefore the majority of CG8810 may be transcribed on the opposite strand as
part of the Dspt4 transcription unit, confusing the annotation. If this
explanation is unclear, please e-mail me.
Referred by: