Gene or accession: CG2140
Missed gene
Comments: The product of gene CG2140 is microsomal cytochrome b5. I presume the
gene symbol should be CYB5.
Cytochrome b5 is not an enzyme itself but an electron transfer protein
in several enzyme systems, including P450 monooxygenase system.
Although there is a number of other genes with cytochrome b5 homology,
CG2140 product (TrEMBL: Q9V4N3) is a protein of exactly the same length
(76% identity) as spectroscopically and functionally characterised
microsomal cyt b5 from house fly <up> SWISSPROT:P49096 ; reference:
Guzov et al. (1996) JBC 271: 26637-26645</up>
BLAST result:
Q9V4N3: 1 MSSEETKTFTRAEVAKHNTNKDTWLLIHNNIYDVTAFLNEHPGGEEVLIEQAGKDATENF 60
MSSE+ K FTRAEVAK+NT W \+IHNN+YDVTAFLNEHPGGEEVLIEQAGKDATE+F
P49096: 1 MSSEDVKYFTRAEVAKNNTKDKNWFIIHNNVYDVTAFLNEHPGGEEVLIEQAGKDATEHF 60
Q9V4N3: 61 EDVGHSNDARDMMKKYKIGELVESERTSVAQKSEPTWSTEQQTEESSVKSWLVPLVLCLV 120
EDVGHS+DAR+MMK+YK+GELV ER++V \+KSEPTW+TEQ+TEESS+KSWL+P VL LV
P49096: 61 EDVGHSSDAREMMKQYKVGELVAEERSNVPEKSEPTWNTEQKTEESSMKSWLMPFVLGLV 120
Q9V4N3: 121 ATLFYKFFFGGAKQ 134
ATL YKFFFG Q
P49096: 121 ATLIYKFFFGTKSQ 134
Also see http://ag.arizona.edu/p450/CYTB5.html