Subject: Helping FlyBase: ADRC-10089
Dear Nicole,
We are currently curating the abstracts for the upcoming 42nd
(Washington, D.C.) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
'Cloning and characterization of a novel actin binding protein in Drosophila
melanogaster.'
You mention a gene that is new to FlyBase, Abp. Do you know which of the
Genome Project CG annotations your gene corresponds to? All the CGs
have corresponding gene records in FlyBase already and we don't like to
make duplicate records for what is actually the same gene unless we
can't avoid it. If your gene does not correspond to a CG then perhaps
you could tell me its map location, as this is valuable information for
the genome annotation project.
Thank you for your help,
with best wishes,
Rachel.
Subject: Re: Helping FlyBase: ADRC-10089
Hi Rachel,
dabp corresponds to CG8953, which right now is named Actn3 by FlyBase..
However, based on sequence homology, only the actin binding domain is
homologous to human alpha-actinin 3 and while the rest is something
else. As well, this putative actin-binding domain is at the C terminal
end rather than the N terminal end as it is on other alpha-actinins, so
I am proposing that this gene is not alpha actinin 3 and I am calling it
drosophila actin binding protein. However, I have not yet demonstrated
that it unequivocally binds actin as of yet, so my name is not
necessarily fit for this gene either. Hope that helps.
Nicole O'Brien