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Citation
Manseau, L.J. (2001). RNA localization meets wingless signaling.  Sci. STKE 2001(92): PE1.
FlyBase ID
FBrf0141743
Publication Type
Note
Abstract
In many tissues in many organisms, messenger RNA (mRNA) is not randomly distributed throughout a cell, but is targeted and accumulated in specific subcellular locations. Signal transduction pathways can be extremely sensitive to gradients of signaling proteins and represent a cellular phenomenon where RNA localization may be important. Manseau discusses how targeting of the RNA for a secreted ligand, Wingless (Wg), is important in promoting proper Wg signaling in early Drosophila embryos and the mechanism for achieving this subcellular targeting. The possible mechanistic models for how restricted wg mRNA distribution influences Wg signaling are also detailed.
PubMed ID
11752665
PubMed Central ID
DOI
10.1126/stke.2001.92.pe1
Related Publication(s)
Research paper

Apical localization of wingless transcripts is required for wingless signaling.
Simmonds et al., 2001, Cell 105(2): 197--207 [FBrf0136813]

Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles.
Wilkie and Davis, 2001, Cell 105(2): 209--219 [FBrf0135682]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. STKE
    Title
    Science's STKE: Signal Transduction Knowledge Environment
    Publication Year
    1999-
    ISBN/ISSN
    1525-8882
    Data From Reference