Subject: Scientific information
From: Grishaeva T.M., Dadashev S.Ya., Bogdanov Yu.F., Vavilov Institute of
General Genetics, Gubkin St.3, 119991, Moscow, Russia
Predicted gene CG17604 is c(3)G.
We have shown by in silico analysis that the predicted Drosophila melanogaster
gene CG17604 may be the known gene c(3)G, crossover suppressor on 3 of Gowen,
causing gross reduction of crossing over and absence of synaptonemal complex
(SC). CG17604 is located at position 36250-36253 kb on the NCBI molecular map.
The related structural protein meets the requirements of the molecular
structure of the protein of transverse SC filaments and fits parameters of
D.melanogaster SC central space. It is a functional homologue of the known SC
proteins \- Zip1p in yeast and SCP1 (SYCP1) in mammals. Our finding is in
accordance with the experimental results from Scott Hawley' lab (Wayson et al,
17th European Research Conference, 1-5 September 2001, Edinburg) and his
personal communication to us on September 23, 2001. Our finding is original in
in silico identifying CG17604 as c(3)G. For details see: Bogdanov et al (2002)
Russ.J.Genet. 38, \#1.