Subject: Helping FlyBase: ADRC-10019
Dear Ruthann,
We are currently curating the abstracts for the upcoming 43rd
(San Diego) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
'Flatline, a novel peptide, stops Drosophila melanogaster heart rate.'
The flt gene is new to FlyBase and though we tested the sequence by
BLAST the best hit was to Ast2 (FBgn0032336) and you say explicitly
that flt does not encode an allostatin. Since the genome has been
sequenced it is possible that a CG gene annotation corresponds to flt.
Do you know which of the Genome Project CG annotations flt corresponds
to? All the CGs have corresponding gene records in FlyBase already and
we don't like to make duplicate records for what is actually the same
gene unless we can't avoid it. If your genes do not correspond to CGs
then perhaps you could tell me their map location, as this is valuable
information for the genome annotation project.
Thank you very much for your help,
with best wishes,
Rachel.
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Rachel Drysdale, Ph.D.
FlyBase (Cambridge),
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Subject: Re: Helping FlyBase: ADRC-10019
Rachel,
Flt or flatline is not an allatostatin in activity, ie, it does not
affect juvenile hormone synthesis. Structurally, FLT is the Drosophila
melanogaster AST C-type peptide, which is also called Drm-AST C and
probably other names, too, unfortunately...sorry.
If this helps, great, otherwise, please get back to me.
regards, \- Ruthann