Gene or accession: CG9488 Release: 2 Gene annotation error Gene CG9488 has incorrect exon/intron structure or translation start site. Gene cDNA sequence: >Ddr virtual cDNA GAACCTGCAAACAGGCCTTGGGCATGGAGTCTGGCGCCATCGCCGACTTTCAAATAACGGCCAGTTCGGCCCATGATAT GGGAAATGTGGGACCACAGCATGCCAGACTTAAGATAGACAACAACGGAGGCGCTTGGTGTCCCAAGCACATGGTATCT CGTGGTCTGACGGAGTACCTGCAAGTCGACCTGCTAGGTGTCCACCTGGTCAGTGCCATACGAACCCAGGGTCGCTTTG GCAAGGGGCAGGGCCAGGAGTATACCGAAGCCTATGTGATTGAGTACTGGAGGCCGGGCCTCAAGAAATGGATTCGATG GAGGAGCCTCCAAGGCAAAGAGGTGCTGCCCGGCAACATAAACACCTACAGCGAGGTGGAGAACGTGCTCCAGCCCAGC GTCTTTGCGTCCAAGGTGCGACTCTATCCCTACAGCCAGTACGATCGCACCGTCTGCCTGCGCGCCGAGATCGTCGGCT GTGCCTGGGAAGAGGGAATTGTATCGTACAGTATTCCCAAGGGCATGCAGAGGGGCATGGACATCGATCTGTCGGACAA AACCTACGATGGATACGAGGAGGGTGATCATTATGTCAACGGTTTGGGCCAACTTGTTGATGGTCAGCGGGGCAAGGAC AACTTTCGAGCCGATATTAATGGCCTTGGCAAAGGTTACGAATGGATTGGCTGGCGAAACGACACTTTGCTCGGGCGTC CAGTTGAAATCATATTCGAGTTTGAGACAGTTCGGAATTTAAGTGCTGTTATCATACACACCAACAACATGTTTTCCAA AGATGTTCAGGTTTTCGTCCATGCCAAAGTGTTTTTCAGCATTGGCGGCCGCCACTTCTCTGGAGAGCCGGTGCAGTTT TCCTATATGCCCGATCTGGTTTTGGATCATGCACGCGATGTGACAATCAAGTTGCATCATCGTCTGGGGCGCTACGTGC AGTTGCATCTATACTTTGCCGCCCGCTGGATGATGATAAGC! GAGATAACGTTCATATCAGTTATATCTCCGAAGCCTATTGACCACCAGGAACCGGAGACGAGCTTCGTCGGCGTCATAA TCACAGTGCTGGGCACAATTATAATGCTGCTGGTGGCATTTATACTACTGATAGTGGCTCGCAACAAGCACGTTAGGAG CAGGGAGAACGGATTGGATGCCTTCCAGCACAACTTCAGCCCGGACACACTTAACGGCAACGGTGTCCTGAAGGTGGTC ACAACAATGGATGACAATGAGTCGTCCATTGACAAGAACAGTCTGTACCATGAGCCCTTCAACGCGAACATGTACACCA GTGCGGCGAGTGCTTGCCCCATGAATGACCTGCAGCGTCAGCATGTATCACCCGACTATACAGATGTGCCGGACATTGT GTGCCAGGACTATGCGGTGCCTCACATGCAGCAGCTGCTGCCCAATGCCCCGCCATGCGGTTCGGGATGCGGAACAGGC ACGGGCACAGGTCCTGGAAGGGGGTCGAGTCCTGAATTCGTTGTTGCCACAGGCAAAGTGACCGCCAGCGCACGCAACT CTCTTAATGCGGCCACACTGCCGCTACCTTCGCCGCCCGTGCCACCGCCGCTGGAGAAATATTACGCAGCAACGCCAGT TAGCAGCAAACCCATGCCAGTGGCGCCGCCGGGATCCCAGAGTAGTGGATCCCTTAGTTCTTCGACTACGGCTGCGACC ACGCCCACCAGTGGGGTGGTGGGCGTAGGCAAACCGCATCATTACAATTTGGATATGAGCGCAAATTTCGCCGACATTA ACGAGGAGCGGGCCAATTGCCAAGTGCAGGAGTTTCCACGTCAGTCGCTGGTCATCGTCGAGAAACTGGGCTCCGGCGT ATTTGGTGAGCTGCATTTGTGCGAAACAAATGTGCTGAATGATCTAACCGAATTTGATTCCCATTGCAGCGCTACCCTC GTGGCAGTGGCCACCCTGCGTCCCGGGGCCAATGACCATCT! GCGTAAGGAATTCCGCAGCAAGGCAAAGCAGCTGGCGCAGCTGAGCGACCCCAATGTGGCCCG! CTTGGTGGGTGCCTGCCTGCGGGACGAGCCCATCTGCATTGTTCAGGACTACTCGCACTGCCTGGGCGACTTGAACCAG TTCCTGCAGGAGCACGTGGCCGAGACCAGCGGACTGATGGCCAAGAAGAGTCTTAGCTTCGGGTGCTTAGTCTACATTG CCACCCAAATTGCATCGGGCATGAAGCATTTGGAGCAAATGAATTTCGTTCATCGGGATCTGGCGACAAGGAGCTGCAT CATTGGCCCCGAACTGTGCGTCAAAGTCTGCTCCATCGGCACTGTGATAAACCGCTCGGCCTACGCGTCGGACTACTGC CAATTGGAGGGCTTCACCGGCAGACAGAGCCAGCCCATGCCCATTCGCTGGATGGCTTGGGAGAGCGTCCTATTGGGCA AGTTCACAACGAAATCGGATGTGTGGTCCTTTGCGGTTGCCCTGTGGGAAATATTGACTTTCGCCAGGGAGCAGCCCTA CGAGCATTTGTCGGACAAAAGTGTAATTGAAAACATCGGCCTCATATATCGGGACTACAAAATGCATGAACTTTTGCCA ATGCCTCCGAATTGTCCGCGAGAGATTTACGATCTGATGTGCGAGTGCTGGCAGCGCGACGAGTCGAGTCGACCCAGTT TCCGCGAGATACATTTGTATCTGCAGCGCAAGAATTTAGGTTTTAAGCCACAGACCCATACACACATGTATTGA Protein sequence: >Ddr virtual protein TCKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFG KGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGC AWEEGIVSYSIPKGMQRGMDIDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRP VEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQ LHLYFAARWMMISEITFISVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFS PDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLL PNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQ SSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLN DLTEFDSHCSATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEH VAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGF TGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNC PREIYDLMCECWQRDESSRPSFREIHLYLQRKNLGFKPQTHTHMY* Comments: The 5 CG's from CG9488 to CG9490 are rerally all one gene, a receptor tyrosine kinase gene we call Ddr (for the DDR class of RTKs). We have no cDNA for it, and I haven't found any ESTs, but the gene structure I put together is mostly unambiguous (based on similarity to other RTKs, and to a partial tandem duplication of Ddr that lies ~100kb upstream.) There are a few questionable splices, but overall it lines up well to the human ortholog. The first exon, which presumably encodes the signal sequence, can't be identified, so my prediction begins with what is probably the second coding exon. The introns are huge, but I did not detect any alternative exons similar to the ones used.
