Subject: Re: FlyBase query: Aplip1
Yes, dp1 is APLIP1.
Thank you.
At  9:51  AM \+0100 02.9.13, Gillian Millburn (Genetics) wrote:
>Dear Dr. Suzuki,
>
>I am a curator working for FlyBase and I have a question about a gene
>mentioned in your conference abstract:
>
>Yagi et al., 1999, A. Dros. Res. Conf. 40: 560A
>
>Analysis of Alzheimer related genes in Drosophila.
>
>In this abstract you mention a clone named 'dp1':
>
>'At the same time, we tried yeast two-hybrid screen to get APPL
>cytoplasmic domain binding proteins, and recovered clones. One clone
>tentatively named dp1 can bind APPL cytoplasmic domain thorough PI
>domain. But no known APP binding proteins showed homology with dp1. dp1
>is also expressed in CNS of embryo. dX11L was also recovered from the
>screen and confirmed APPL binding activity.'
>
>I am writing to ask whether or not 'dp1' is the same gene as 'APLIP1'
>(APP-like protein interacting protein 1) which you describe in your
>paper:
>
>Taru et al., 2002, J. Biol. Chem. 277(22): 20070--20078
>
>If they are the same gene then I will be able to merge the information
>in FlyBase currently under 'dp1' into the APLIP1 gene record,
>
>Gillian
>
>--------------------------------------------------------------
>Gillian Millburn.
>
>FlyBase (Cambridge),
>Department of Genetics,
>--------------------------------------------------------------
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\----------------------
Toshiharu Suzuki, Ph.D
Professor & Head
Laboratory of Neuroscience
Graduate School of Pharmaceutical Sciences
Hokkaido University
Sapporo 060-0812 JAPAN
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