Subject: Re: gene nomenclature
Hello again Rachel,
We have demonstrated that two Drosophila cDNAs (LD11247 and RE64552) are
both able to fully complement a yeast sphingosine kinase mutant indicating
that CG32484 (CG2159) and CG1747 both have sphingosine kinase
activity. This is also suggested by their high degree of sequence
similarity to human, mouse, and yeast sphingosine kinases. Therefore, we
suggest the following changes to the gene nomenclature:
CG1747 changed to Sphk1
CG32484 changed to Sphk2
This work will be discussed in a forthcoming publication tentatively titled:
Identification and analysis of Drosophila sphingosine kinases.
Deron Herr, Michael Creason, Henrick Fyrst, Karie Heinecke, Julie Saba, and
Greg Harris.
Thank You,
Deron Herr
San Diego State University
(619)594-5038