Dantonel, J.C., Wurtz, J.M., Poch, O., Moras, D., Tora, L. (1999). The TBP-like factor: an alternative transcription factor in Metazoa? Trends Biochem. Sci. 24(9): 335--339.
FlyBase ID
FBrf0182706
Publication Type
Review
Abstract
Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms. Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes. Thus, the existence of TLFs presents a challenge to the doctrine that TBP is a universal regulator of transcription in metazoans.
