Subject: Helping FlyBase: ADRC-50196
Dear William,
We are currently curating the abstracts for the upcoming 46th
(San Diego) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
A role for the Fray kinase in nerve glia to regulate ion homeostasis.
You mention a gene symbol that is new to FlyBase, NCC69. Do you know
which of the Genome Project CG annotations your gene corresponds to?
All the CGs have corresponding gene records in FlyBase already and we
don't like to make duplicate records for what is actually the same gene
unless we can't avoid it. The CG symbols become synonyms when an
annotation is named with a more descriptive or functional name.
Also, if you have let me know the full name for NCC69 I can enter it into
the database from the outset.
With best wishes,
Rachel.
Subject: Re: Helping FlyBase: ADRC-50196
Hi Rachel,
NCC69 corresponds to CG4357. I have tentatively named it that because
it is a homolog of the mammalian NCC (sodium chloride cotransporter)
and NKCC (sodium potassium chloride cotransporter). I don't yet know
which ions pass through NCC69. The '69' refers to its location in the
Drosophila genome (to distinguish it from NCC83). Since I submitted
the abstract, it has come to my attention that some people object to
the 'cotransporter' nomenclature, and prefer to use the term 'solute
carrier.' This is to distinguish this family of molecules from the
ABC transporters. Flybase uses the term 'symporter' for CG4357.
However, the vast majority of the 'functional' literature refers to
this class of molecules as cotransporters.
That's the story behind NCC69. I don't know if Flybase wants to
rename CG4357 at this point, or if it would be better to wait until
we more information on its function and/or decide whether flies will
follow the 'solute carrier' nomenclature of the genome jocks.
Hope this is helpful. Please let me know what you decide.
Best,
Billy