Boikova, T.V., Orlando, V., Lupo, R., Bogachev, S.S. (2005). [The M/SAR elements of the bithorax complex in Drosophila melanogaster] Genetika, Moscow 41(11): 1467--1479.
FlyBase ID
FBrf0190782
Publication Type
Research paper
Abstract
The bithorax (BX) complex of Drosophila is a complex polygenic region with a multifactorial system of regulation. One of the levels of the regulatory system of the BX complex is its association with the nuclear skeleton structures through a specific interaction of the M/SAR DNA with the nuclear matrix proteins. In the present work, M/SAR elements were mapped on the molecular-genetic map of the region. All of the elements examined were found to colocalize with regulatory elements and form clusters that restrict/bracket the genetically active domains. All M/SAR DNA revealed was shown to bins specifically to the purified Drosophila melanogaster lamin.
