Leulier, F. (2009). Tuning down NF-kappaB signaling by DUBs: a fly case.  Cell Host Microbe 6(4): 294--296.

FBrf0208944

Note

The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-kappaB signaling cassette and shares striking similarities with the mammalian TNF-R1 pathway. Thevenon et al. (2009) reveal how dUSP36, a deubiquitinating enzyme of the ubiquitin-specific protease (USP) family, prevents the constitutive activation of the IMD pathway by resident gut bacteria.