Moskalev, A., Shaposhnikov, M. (2011). Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.  Aging 3(4): 391--394.

FBrf0213761

Research paper

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

PMC3117454 (PMC) (EuropePMC)