Strutt, D., Vincent, J.P. (2010). Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?  Sci. Signal. 3(148): pe43.

FBrf0214080

Note

Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.