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Citation
Stocker, H. (2011). Growth control: Myc and Yorkie get connected.  Curr. Biol. 21(1): R37--R39.
FlyBase ID
FBrf0214485
Publication Type
Note
Abstract
Recent work shows that the transcriptional coactivator Yorkie, which is negatively regulated by the Hippo tumor suppressor pathway, promotes the transcription of the proto-oncogene Myc and requires Myc function to drive growth. In turn, Myc keeps the concentration of Yorkie in check via negative feedback regulation.
PubMed ID
21215937
PubMed Central ID
DOI
10.1016/j.cub.2010.11.057
Related Publication(s)
Research paper

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap.
Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 [FBrf0212043]

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells.
Ziosi et al., 2010, PLoS Genet. 6(9): [FBrf0211944]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference