Zarnescu, D.C., Zinsmaier, K.E. (2009). Ferrying wingless across the synaptic cleft.  Cell 139(2): 229--231.

FBrf0215067

Note

Secreted Wnt morphogens mediate cell-cell communication, but the mechanism of Wnt transfer between cells is unknown. Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft. In postsynaptic muscles, Evi promotes Frizzled-2 trafficking.