Duvall, L.B., Taghert, P.H. (2011). Circadian rhythms: biological clocks work in phospho-time.  Curr. Biol. 21(9): R305--R307.

FBrf0215210

Note

The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation.