Galbán, S., Brady, G.F., Duckett, C.S. (2008). Caspases and IAPs: a dance of death ensures cell survival.  Mol. Cell 32(4): 462--463.

FBrf0215766

Note

In this issue of Molecular Cell, Ditzel et al. (2008) show that DIAP1 polyubiquitinates DRONC, DCP-1, and drICE, leading to their nondegradative inactivation. Surprisingly, activation of DIAP1 requires caspase-mediated cleavage, revealing an elegant feedback mechanism by which caspases regulate their own fate.

PMC2744384 (PMC) (EuropePMC)