FB2026_03 , released September 17, 2026
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Citation
Kalderon, D. (2008). Hedgehog signaling: a smoothened conformational switch.  Curr. Biol. 18(2): R64--R66.
FlyBase ID
FBrf0215971
Publication Type
Note
Abstract
An intracellular conformational switch in the serpentine transmembrane protein Smoothened appears to underlie Hedgehog pathway activation. The switch is gated by electrostatic interactions that are regulated by multiple phosphorylations, potentially endowing a dose-dependent response.
PubMed ID
18211840
PubMed Central ID
DOI
10.1016/j.cub.2007.11.035
Related Publication(s)
Research paper

Hedgehog regulates smoothened activity by inducing a conformational switch.
Zhao et al., 2007, Nature 450(7167): 252--258 [FBrf0202820]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference