Chandrasekhar, S., Pushpavalli, S.N., Chatla, S., Mukhopadhyay, D., Ganganna, B., Vijeender, K., Srihari, P., Reddy, C.R., Janaki Ramaiah, M., Bhadra, U. (2012). aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle.  Bioorg. Med. Chem. Lett. 22(1): 645--648.

FBrf0219092

Research paper

aza-Flavanones have been identified as a new class of selective microRNA inhibitors. These compounds were found to arrest cell cycle via a novel cross species microRNA-dependent regulatory pathway interpreting an unexpected link between cell cycle arrest and microRNA mediated control in cancer.