Li, W., Dubnau, J. (2012). A prion-mediated mechanism for memory proposed in Drosophila.  Neuron 76(2): 260--262.

FBrf0219735

Note

Memories are remarkably persistent, but rely on transient signaling. The prion-like properties of CPEB suggested a solution to this problem. The paper by Krüttner et al. (2012) in this issue of Neuron demonstrates that the prion-like domain of Drosophila CPEB functions independently of its RNA-binding domain for memory.

PMC3488862 (PMC) (EuropePMC)