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Citation
Reichardt, I., Knoblich, J.A. (2013). Cell biology: Notch recycling is numbed.  Curr. Biol. 23(7): R270--R272.
FlyBase ID
FBrf0222797
Publication Type
Note
Abstract
During asymmetric cell division, the Notch regulator Numb segregates unequally to establish different cell fates in the two daughter cells. Numb is thought to act as an endocytic protein. Two new studies show that Numb antagonizes Notch signaling by also regulating recycling of Sanpodo-Notch complexes via AP-1.
PubMed ID
23578871
PubMed Central ID
DOI
10.1016/j.cub.2013.03.013
Related Publication(s)
Research paper

Numb inhibits the recycling of sanpodo in Drosophila sensory organ precursor.
Cotton et al., 2013, Curr. Biol. 23(7): 581--587 [FBrf0221275]

Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila.
Couturier et al., 2013, Curr. Biol. 23(7): 588--593 [FBrf0221279]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference