Siriaco, G., Tamkun, J.W. (2013). A Histone Timer for Zygotic Genome Activation.  Dev. Cell 26(6): 558--559.

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Note

Histone H1 variants play key roles in the regulation of higher-order chromatin structure and have been implicated in numerous developmental processes. In this issue of Developmental Cell, Pérez-Montero et al. (2013) present evidence that the Drosophila histone H1 variant dBigH1 prevents premature activation of the zygotic genome during early embryogenesis.