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Citation
Bechtel, W., Helmstädter, M., Balica, J., Hartleben, B., Schell, C., Huber, T.B. (2013). The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.  Autophagy 9(7): 1097--1099.
FlyBase ID
FBrf0224559
Publication Type
Note
Abstract
Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.
PubMed ID
23614954
PubMed Central ID
PMC3722319 (PMC) (EuropePMC)
DOI
10.4161/auto.24634
Related Publication(s)
Research paper

Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.
Bechtel et al., 2013, J. Am. Soc. Nephrol. 24(5): 727--743 [FBrf0221492]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Autophagy
    Title
    Autophagy
    Publication Year
    2005-
    ISBN/ISSN
    1554-8627 1554-8635
    Data From Reference